Scientists synthesize new nano-luminescent materials

Recently, the research team of Yuqiang Qiang, a researcher of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, has collaborated with Sha Yinlin's research group of Peking University School of Basic Medicine to design and synthesize a new type of nano-luminescent material. The two-photon power therapy based on this type of gold nanoclusters has the advantages of high spatial selectivity, safety, high efficiency, and no need to avoid the photoperiod. It has a good clinical transformation in the treatment of tumors, especially gliomas, solid tumors, etc. prospect. Related research achievements have applied for two invention patents, which were published online in the "American Chemical Society Nano" recently.

The researchers designed and synthesized a gold nanocluster with dihydrolipoic acid as the ligand, which has strong free radical generating properties under light, has a very good killing effect on tumor cells and tissues, and is an excellent performance The photosensitizer for photodynamic therapy has far better efficacy than the clinically used Ella photosensitizer.

"The photodynamic therapy system is a new weapon for humans to deal with tumors, just like Nezha against monsters." Yu Qiang introduced, "Among them, the performance of photosensitizers is the key to determine the efficacy of photodynamic therapy for tumors. However, the photosensitizers currently used in clinics Visible light excitation, tissue penetration depth is small, it is difficult to use for the treatment of solid tumors and deep tumors. Moreover, patients need to avoid light for several weeks after treatment, which brings great inconvenience to life. "

The new material synthesized this time has excellent two-photon properties, and its two-photon absorption cross section is high, which can be excited by near-infrared laser, which effectively increases the depth of irradiation and can be used for the treatment of solid tumors. More importantly, the material has good biocompatibility, and the treatment process does not need to avoid light, which greatly improves clinical maneuverability.

It is understood that tumor photodynamic therapy is the use of tumor-targeted photosensitizers to generate a large amount of reactive oxygen radicals under laser irradiation to destroy tumor tissue. Compared with conventional tumor treatment methods such as radiotherapy and chemotherapy, photodynamic therapy has the characteristics of high spatial selectivity, resistance to drug resistance, and low system toxicity. However, the lack of matching two-photon photosensitizers currently greatly limits its clinical application. (Reporter Ding Jia)

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